Course Days/Hours: 2pm-4pm on April 1, 2, 3, 8, 9, 10, 15, 16, 17
Location: Genentech Hall S202
Instructors: James Fraser
This mini-course will be a survey of recent and classic papers on antibiotic resistance with an emphasis on evolutionary biology, biochemical mechanisms, and new ideas for chemical matter.
Each students will serve as Discussion Leaders (pre-assigned below) for one paper topic. Everyone should be prepared for class by having read the paper carefully. The Discussion Leader will prepare a talk similar in content and quality to a Tetrad or QBC Journal Club presentation, with an estimated 30-40 minute duration (noting that interruptions and discussion may take us closer to an hour).
Good Introductory Resources:
Industry retrospectives on antibiotic development
Additional/Alternate reading:: Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins
Additional/Alternate reading: Drug combinations: a strategy to extend the life of antibiotics in the 21st century, Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance., Accelerated evolution of resistance in multidrug environments.