Engineering Life: A Flipped Classroom with iBiology
Spring 2015 Syllabus
Course Days/Hours: 3pm-5pm on May 15, 18, 20, 22, 26, 27, 29
Location: Genentech Hall S261
Instructors: Ron Vale and James Fraser;
Course Description:
How did life evolve? How can understand the principles of biological systems to create new proteins, new chemicals, biological structures, cells and tissues? We will cover these topics in a “flipped course” where you will hear online lectures from scientific leaders in the field, read a paper, and then discuss as a group. We have chosen diverse topics within this subject area, since they provide a window into how scientists tackle problems using different approaches. We will meet for 7 sessions. Prior to each session, students and faculty will view the three parts of an iBiology talk (usually 3 x ~30 min segments) and read one research paper from the speaker which is also discussed in the talk. For the first session, two talks are assigned (they can be viewed at anytime prior to the course, as is true also of the other lectures). A series of prompt questions will be prepared to help guide student-faculty discussion as a group. One student and faculty member will be assigned as a discussion leader, but all students will be expected to be well prepared to engage in the discussion.
Course structure
2 students will serve as Discussion Leaders (pre-assigned below) for each class. Everyone should be prepared for class by having viewed the talks and read the paper carefully.
Discussion Leaders will need do advance work. The goal is to derive a set of questions that can lead to a provocative discussion with your classmates. Beyond our class, we would like the Discussion Leaders also to invest effort and produce a set of “Teaching Tools” which could be posted on the iBiology web site (with your name listed as having prepared them). Then, other teachers (mostly undergrad teachers) can benefit and lead discussions or make assignments for their classes on these lectures. It is also good opportunity for you to learn how to produce useful education material, which might prove useful later in your life. We can help you with revising your Teaching Tools (which will be part of the learning process) before we post them and have created an online guide to preparing Teaching Tools. Remember, the teaching tools overall are aimed for upper level undergraduate classes.
Course goals/timelines:
- Prepare a set of Discussion Questions (e.g. 5 (or a couple more if you want) on each part of the assigned iBioSeminars Talk and on the paper (see instructions on Teaching Tools). These questions should be distributed to your classmates 2 days before the assigned discussion, so you will need to view the material, discuss with your assigned co-leader, and then email to the group. You can start on this before the class starts (obviously necessary for the first 2 classes). This is why we are distributing this information in advance. You do not need to have written answers for the purpose of our mini-course discussion (but will need for the assignment below).
- Prepare Teaching Tools on your assigned speaker according to guidelines and examples below by June 1. This will include more material (e.g. overview, review questions, etc) for undergrads. For the Discussion Questions, you can also see what worked or did not work in our session or come up with new questions based upon the class discussion. If you send us a preliminary version of your Teaching Tools, we will provide you with feedback so that you can revise and also learn from the experience. Some of the iBiology staff at UCSF will likely help with feedback as well.
For our UCSF class, our discussion time will focus primarily on the Research Lectures (part II and III of the iBiology Talk (or the main talk for Tejal Desai) and on the assigned paper. However, we also discuss the Introduction Talk from the point of view of the effectiveness of the presentation. Did you like the talk and the style of the speaker? What techniques did the speaker use well to engage the viewer or get a point across? To be successful in science, you will have to become a good communicator, so it is valuable to analyze what you think constitutes a successful talk (and also appreciate that there are various strategies for crafting a good talk).
If you want to talk to us about preparing your discussion session, please feel free to talk to us in advance with the faculty assigned for your discussion day.
May 15
- Leaders: Kelsey Haas, Jasper Williams
- Primary Faculty: Ron
Jack Szostack - The Origins of Life on Earth
Assigned Paper:
Dianne Newman - Microbial Diversity and Evolution
Assigned Paper:
- Discussion Questions: Szostak and Newman
May 18
- Leaders: Aditya Anand, Lynn Wang
- Primary Faculty: Jaime
David Baker - Protein Design
Assigned Paper:
- Discussion Questions: David Baker
May 20
- Leaders: Ben Barsi-Rhyne, Becky Anderson
- Primary Faculty: Jaime
Chaitan Khosla - Polyketide Assembly Lines
Assigned Paper:
- Discussion Questions: Chaitan Khosla
May 22
- Leaders: Karen Cheng
- Primary Faculty: Ron
William Shih - Nanofabrication via Structural DNA
Assigned Papers:
- Ke, Y., Ong, L.L., Shih, W.M., and Yin, P. (2012). Three-Dimensional Structures Self-Assembled from DNA Bricks. Science 338, 1177–1183.
- Derr, N.D., Goodman, B.S., Jungmann, R., Leschziner, A.E., Shih, W.M., and Reck-Peterson, S.L. (2012). Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold. Science 338, 662–665.
- Discussion Questions: William Shih
May 26
- Leaders: Elijah Martin, Tess Veuthey
- Primary Faculty: Jaime
Kristala Prather-Jones Synthetic Biology and Metabolic Engineering
Assigned Paper:
- Discussion Questions: Kristala Prather
May 27
- Leaders: Karina Perlaza, Brian Yang
- Primary Faculty: Ron
Sangeeta Bhatia Tissue Engineering
Assigned Paper:
- Discussion Questions: Sangeeta Bhatia
May 29
- Leaders: Valentina Garcia, Lindsay Osso
- Primary Faculty: Ron
Robert Langer Biomaterials and Delivery Systems
Assigned paper:
- Discussion Questions: Robert Langer
Desai/Bhisitkul Advancing the Treatment of Retinal Disease
No paper assigned