Fraser Lab Lab Courses

The Fraser lab is supportive of learning through research experiences, and has participated in a number of courses for first year graduate students which challenge students with real research challenges in which they conduct experiments and analyze data to answer interesting new questions.

Biophysics 204A: Macromolecular Methods

Fluency in multiple biophysical methods is often critical for answering mechanistic questions. To train the next generation of biophysicists at UCSF, we have decided to alter the traditional didactic structure by creating a new 6 week “Macromolecular Methods” class that places data collection at the beginning of the course.

Biophysics 205A: Physical Underpinnings of Biological Systems (PUBS)

The PUBS course is a hands-on, project-based course that integrates proteomics, deep mutational profiling (Fowler and Fields, Nature Methods, 2014), and computational biology.

PUBS is now run by Martin Kampmann and examines alpha synuclein!

PUBS Students in the teaching lab

Engineering Life: A Flipped Classroom with iBiology

How did life evolve? How can understand the principles of biological systems to create new proteins, new chemicals, biological structures, cells and tissues? We will cover these topics in a “flipped course” where you will hear online lectures from scientific leaders in the field, read a paper, and then discuss as a group. Tetrad minicourse.

iPQB Reproducibility and Rigor

Mechanisms of Antimicrobial Resistance

This minicourse will be a survey of recent and classic papers on antibiotic resistance with an emphasis on evolutionary biology, biochemical mechanisms, and new ideas for chemical matter. Tetrad minicourse.

Inquiry Immersion - DRUG DESIGN: Why is it so hard to design new small molecule drugs?

The goal for Inquiry Immersion and the interprofessional Mini-Courses is to help first year students in the healthcare professions shift their conception of medicine as a series of facts to a vision of medical practice as consistent engagement with an ever-evolving and imperfect body of knowledge. Focused Mini-Courses offer students the chance to take a deep dive into a controversy or dilemma and explore the boundaries of existing research and scholarship with expert researchers.

Structure based drug design promises to revolutionize drug discovery, yet despite decades of promise, progress remains intermittent. This course will give students an appreciation for the experimental and computational advances that have led to this optimism, while also pointing out the limitations that currently prevent completely unattended design.